The Secretariat of the Ghana Natcom
The Secretariat of the Ghana National Commission for UNESCO serves as the main channel of communication between the Government of Ghana and UNESCO. It is headed by a Secretary-General and operates under the supervision of the Chairman of the Commission.
PAST SECRETARIES-GENERAL OF THE GHANA NATIONAL COMMISSION FOR UNESCO
| NO. | NAME | DESIGNATION | PERIOD |
| 1 | Mr. Casely M. Obuobisa Mate | Secretary-General | 1954 – 1961 |
| 2 | Mr. E. T. B. Lomotey | Secretary-General | 1961 – 1967 |
| 3 | Mrs. E. V. N. Asmah | Ag. Secretary-General | 1977 – 1978 |
| 4 | Mr. John Kusi Achampong | Secretary-General | 1978 – 2004 |
| 5 | Mrs. Charity Amamoo | Secretary-General | 2004 – 2013 |
| 6 | Mrs. Sylvia Lutterodt | Ag. Secretary-General | 2009 – 2011 |
| 7 | Mr. Riche-Mike Wellington | Officer-in-Charge | 2013 – 2016 |
| 8 | Mrs. Ama Serwah Nerquaye-Tetteh | Ag. Secretary-General | 2017 – present |